I get this error whenever I try to open or make an image. I haven't changed any settings on RWP since the last time I used it. I held control and shift while opening RWP as suggested, I allowed it, and the problem persists. Even after uninstalling and reinstalling it doesn't work.
RWCE works fine.
Title was cut... it's meant to be "Configuration may be corrupted. Reset configuration by holding CTRL and SHIFT while starting the application."
While holding the keys, did a window pop up asking you whether you want to reset the configuration and did you say yes?
Yes to both, and when I tried reinstalling it asked me if I wanted to fix it (while the old app was in the recycle bin), I tried that and it didn't do anything. So I did a normal reinstall but the problem persists.
You may try to manually delete the configuration file. You can find in the %APPDATA%\RealWorld\RWPaint folder and it should be named Config.2013.1
Or you can try the portable version, it uses a different configuration file.